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KMID : 1202020100030020149
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Journal of Korean Thyroid Association
2010 Volume.3 No. 2 p.149 ~ p.154
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Preoperative Cytological Diagnosis of Follicular Thyroid Carcinoma and Huthle Cell Carcinoma
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Kim Won-Gu
Yim Ji-Hye
Kim Eui-Young
Kim Tae-Yong
Gong Gyung-Yup
Yoon Jong-Ho
Hong Suck-Joon
Kim Won-Bae
Shong Young-Kee
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Abstract
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Background and Objectives : Follicular thyroid carcinoma (FTC) and hurthle cell carcinoma (HCC) are relatively uncommon in iodine sufficient area, and there were few reports about these tumors. This study aimed to evaluate the preoperative diagnosis of FTC and HCC in Korea.
Materials and Methods : This retrospective study enrolled 208 patients with FTC and 46 patients with HCC who underwent initial thyroid surgery between 1995 and 2006 in Asan Medical Center, Seoul, Korea.
Results: There was no significant difference between FTC and HCC in basal clinicopathological parameters, except age and lymphovascular invasion (LVI). Patients with HCC were older (p=0.008), and had more LVI (p=0.008). Preoperative fine needle aspiration cytology (FNAC) diagnoses of FTC patients were follicular neoplasm (FN) in 84 cases (40%), hurthle cell neoplasm (HN) in 4 cases (2%), other malignancy in 26 cases (13%), and benign or indeterminate results in 89 cases (43%). FNAC diagnosis of HCC patients were 21 cases (46%) of HN, 8 cases (17%) of FN, 6 cases (13%) of other malignancy, and 11 (24%) cases of benign or indeterminate results.
Conclusion: The results of FNAC were somewhat helpful for decision of thyroidectomy for the patients suspected FTC and HCC. However, clinical suspicion is also important for diagnosis of FTC and HCC even if the FANC results of nodules were benign or indeterminate.
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KEYWORD
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Thyroid neoplasm, Follicular carcinoma, Hurthle cell tumor, Cytology, Diagnosis
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